Telomerase and Oxidative Stress in Metabolic Syndrome

Abstract

ABSTRACT newlineBACKGROUND newlineMet-S is a group of risk factors for cardiovascular disease, stroke, and type2 diabetes, as described by the WHO.This study applies the Met-S criteria developed by the ATP III of the National Cholesterol Education Program. newlineOBJECTIVES newlineIn this analysis, we hope role of how telomerase and oxidative stress in to metabolic syndrome. newline newlineMATERIALS AND METHODS newlineThe proposed study was conducted at SLN Medical College andHospital, Koraput,Odisha.This was a prospective observational study. A sample size of 360 subjects fulfilling the inclusion and exclusion criteria was included. The study subjects were divided into two groups. newlineA (MS patients) and B (Metabolically Healthy). After receiving the signed informed consent form from the study subjects,detailed history of each patient including medications and diet was obtained. Anthropometric parameters like blood pressure, BMI, waist circumference was measured. newlineRESULTS newlineThe study demonstrated Among a total of 183 control subjects, 114 were males whereas, number of females was 69. In Met-S positive (case subjects) we found total males to be 106 and females to be 77. newlineFor control subjects, height, weight, BMI and waist were found to be 158.37 ± 10.01, 56.48 ± 7.84, 21.40 ± 3.47 and 63.20 ± 12.33 respectively. newlineFor case subjects the aforesaid indices were found to be 152.80 ± 8.32, 82.02 ± 11.52, 36.02 ± 7.86 and 95.67 ± 9.75. newlineConclusion: newlinewe undertook Met-S in an overall perspective not just as a disease. Sedentary life style, rapid rate of urbanization and dietary moderation are attributers of Met-S declared Met-S as pathological disorders wanting first attention as the world is facing pre-crisis situation in terms of obesity. ATP-III guidelines precisely described Met-S as a cluster of three (or more) of the following: hypertension, central obesity and hyperlipidemia. newline