Studies on Bioactive Nitrogen Heterocycles Synthesis and Biological Evaluation of Tetrahydroprido 3 and 4 d Pyrimidines and Imidazo 4 and 5 d Pyrimidines

Abstract

quotThe work carried out during my research tenure has been collected in the form of a thesis entitled STUDIES ON BIOACTIVE NITROGEN HETEROCYCLES: SYNTHESIS AND BIOLOGICAL EVALUATION OF TETRAHYDROPYRIDO[3,4-d]PYRIMIDINES AND IMIDAZO[4,5-d]PYRIMIDINES is classified into four chapters. newlineChapter-1: An overview of 1,3,4-oxadiazole-2-amine and their derivatives newlineThis chapter explains the goal and extent of the current study, as well as the introduction, biological uses, and synthesis of the 1,3,4 Oxadiazole nucleus. newlineChapter-II: Synthesis, Characterization, Computational studies and Biological Assessment of Innovative 5-(Pyrazin-2-yl)-1, 3, 4-oxadiazol-2-amine Derivatives. newlineThe synthesis of heterocyclic Pyridine mixed 1,3,4 Oxadiazol-2-amine scaffolds is covered in this chapter. The synthesis, in silico ADME, docking investigations, and antibacterial, antifungal, and novel heterocyclic analogues of newly N-acylated derivatives of 5-(Pyrazin-2-yl)-1, 3, 4-oxadiazol-2-amine newlineChapter-III: PART-A: Synthesis, characterization, computational studies and biological assay of new 5-(pyridine-2-yl)-1,3,4-oxadiazol-2-amine derivatives newlineThis chapter describes the synthesis, anti-bacterial, anti-fungal activity and insilico ADME, docking studies of N-Acylated derivatives of 5-(pyridine-2-yl)-1,3,4-oxadiazol-2-amine. newlineChapter-III: PART-B: Synthesis, Characterization, Computational studies and Biological assay of 5-(3,4,5-trimethoxyphenyl)-1,3,4-oxadiazol-2-amine derivatives. newlineThe synthesis, antimicrobial, antifungal, and insilico ADME docking studies of novel amide derivatives of 5-(3,4,5-trimethoxyphenyl)-1,3,4-oxadiazol-2-amine are covered in this chapter. newlineChapter-IV: Synthesis, in-vitro anti-cancer, anti-bacterial and anti-fungal potential of New 5-(4-(benzyloxy)phenyl)-1,3,4-oxadiazol-2-amine derivatives and their computational studies newlineThe synthesis of 5-(4-(benzyloxy)phenyl)-1,3,4-oxadiazol-2-amine derivatives is covered in this chapter. Every newly created synthetic chemical assessed Insilco ADME and docking score. The anti-cancer