Studies on dihydrolipoamide dehydrogenase of leishmania donovani and itsbiochemical functions

Abstract

Our whole work provides clear evidence about the existence of two different variants of LdDLDH enzyme which has a difference in catalytic activity LdDLDH Variant2 showed high physiological catalytic activity compare to LdDLDH Variant1 during biochemical studies These enzymes belong to the flavo group that was confirmed by estimation of FAD flavo compound cofactor by HPLC analysis Other than a physiological activity such as the conversion of DLD into LA natural substrate it also performs...