Evaluation of Salivary Leptin Ghrelin and Chemerin in overweight children using ELISA and its association with tooth eruptio

Abstract

Introduction: Oral health enables an individual to speak, eat and newlinesocialize without active disease, discomfort or embarrassment. Oral newlinehealth is fundamental to health and well-being, significantly having an newlineimpact on quality of life. It has become clear that causative and newlinepredisposing risk factors in oral diseases are often the same as those newlineimplicated in the major general diseases. newlineAim: To assess the levels of Salivary Leptin, Ghrelin, Chemerin in newlineoverweight children and to compare it with non-obese children and to newlinesee whether it can be used as a marker for obesity. To find the newlineassociation of salivary Leptin, Ghrelin, Chemerin with tooth eruption. newlineMaterials and Methods: An in vivo cross- sectional study on the newlinesalivary samples obtained from overweight children to assess the levels newlineof Leptin, Ghrelin and Chemerin and simultaneous correlation with newlinetooth eruption.The study was designed to examine the salivary levels of newlineLeptin, Ghrelin and Chemerin in overweight children. The study was newlineconducted in and around the districts of Erode. Independent t test was newlineused to compare the means of levels Leptin, Ghrelin and Chemerin between newlinethe two groups. newline11 of 172 newlinePearson s correlation was used to assess the correlation of Leptin, Ghrelin newlineand Chemerin to the eruption of teeth and one way ANOVA followed by Post newlinehoc analysis was used to find the significance between leptin, ghrelin and newlinechemerin. Significance was fixed as 5% (and#945; = 0.05). plt0.05 was considered newlinesignificant and pgt0.05 was considered as not significant. newlineResults: The results of this study increased levels of the molecules newlineLeptin, Ghrelin and Chemerin in the saliva of overweight children with a newlineBMI above the 85 newlineth percentile in comparison with the healthy, non-obese newlinechildren with a BMI well below the 85 newlineth percentile. newlineConclusion: Leptin, Ghrelin and Chemerin in addition to maintaining newlinethe energy balance and satiety levels in the body thereby contributing to newlinethe total fat content, it also plays significant roles in tooth eruption newlinethrough various signalling mechanisms.