Design Synthesis and Evaluation of Hybrid Heterocyclic Derivatives against Mycobacterium Tuberculosis

Abstract

Mycobacterium tuberculosis (M.TB) bacillus causes tuberculosis (TB), is a chronic disease affecting lungs and other organs such as brain, intestines, kidneys and spine. TB is the most common infectious agent other than HIV/AIDS and is one of the top ten causes of death. Resistance to medicines develops in TB bacteria due to genetic alterations and recent molecular insights suggest that accumulation of mutation in the individual drug target genes is the primary mechanism of MDR-TB. The long treatment time, severe adverse effects and resistance problem prompts researchers in search of new anti-TBtargets and drugs newline