Evaluation of effect of pine nut oil on obesity and obesity linked colorectal cancer in Wistar rats

Abstract

Obesity has become a major health concern worldwide. It is associated with an increased risk for the development of various life-threatening disorders such as cardiovascular diseases, diabetes, hypertension, and certain types of cancer. Obesity is characterized by excessive fat accumulation that may impair health. A key determinant of obesity is the balance between ingested calories and the body s basal energy expenditure. WAT is an energy reservoir and secretes several hormones and cytokines that are involved in metabolic homeostasis. In this study effect of pine nut oil on high fat diet induced obesity and obesity linked colorectal cancer was evaluated. It was observed that PNO supplementation decreased the severity of obesity and its complications which may be mediated by modulation of the leptin- adiponectin axis and signaling pathways involved in energy homeostasis. The mechanism underlying its potential anti-obesogenic effects may be related to reducing the pro-inflammatory milieu. Current study suggests that visceral epididymal adipose tissue is metabolically more active in combating obesity than visceral retroperitoneal adipose tissue. The present study also observed that HFD-induced obesity does increase the risk of developing CRC, as evidenced by an increase in the number of tumor markers. This may be related to obesity-induced chronic inflammation as we observed a significant effect on proinflammatory cytokines. PNO supplementation significantly affects the outcome of obesity-induced CRC by reducing the associated inflammatory changes and associated signaling parameters. Overall, PNO demonstrates potential anti- obesogenic and chemopreventive effects by lowering obesity and associated signaling parameters. However, further work needs to be done in order to clearly delineate the mechanisms involved. newline