Development of Novel Glycoconjugates via 1 3 Dipolar Cycloaddition Reaction

Abstract

newline The designing and development of novel molecular constructs that exhibits specific properties has always remained the most important objective of an organic chemist. Like all sciences, chemistry occupies a unique place in developing our pattern of understanding of the universe. We need to study the molecules of nature due to two reasons as they are very interesting in their own respect and their functions are also important to our lives. In this context, organic chemistry deals with the broader aspects, related to the studies of all life forms. The basic challenge which lies in front of organic chemists is to construct such type of new entities that can mimic naturally occurring moieties and can even perform better function as compared to them. newlineThe area of synthetic organic chemistry, particularly the one which utilizes the synthetic modification of carbohydrates has experienced explosive growth during the last two decades. The reason behind this increasing demand of carbohydrate based molecular constructs, is to develop a clear understanding about their role in biological, medicinal and pharmacological investigations. These molecules are involved in a variety of fundamental biological processes like cell differentiation, embryonic development, fertilization, pathological processes including bacterial and viral infection, inflammatory disease, cancer etc. Hence, the modification of carbohydrate molecules is of paramount importance. A key factor which accelerated the synthetic modification of carbohydrates is the introduction of 1,3-dipolar cycloaddition reaction between azides and alkynes in presence of Cu(I) catalyst, generally termed as click reaction , which allowed an easy access of simple to complex glycoconjugates.