Protection of Biomolecules including Metalloenzymes against Reactive Oxygen Species by Ergothioneine and Selenoneine Derivatives A Detailed Mechanistic Study

Abstract

The copper ion is essential in our life which mostly acts as a cofactor in a number of vital processes. Its main role is to exchange electrons for oxidative metabolism, a neurotransmitter and hormone biosynthesis, free-radical detoxification, or iron absorption. newlineIn this context, we have synthesized various sulfur and selenium analogues of ergothioneine derivatives and performed detailed experimental and theoretical studies to understand the mechanism by which these N-heterocyclic based chalcogens (thiones and selones) protect metalloenzymes against toxic ROS, particularly H2O2 and HO radicals. In this thesis work, we have focused on exploring the role of various derivatives of N-heterocyclic based chalcogens in protecting biomolecules against redox-active metal-mediated oxidative damage. We have also discussed the role of H-bonding in enhancing their antioxidant activity. Additionally, we have developed a highly potent Tyrosinase enzyme inhibitor-based on simple structure-activity relationship, which will have a huge significance in food and cosmetic industries.