Biological Activities of Peptides Identified and Chemically Synthesized from Innate Immune Molecules of Freshwater Teleost

Abstract

Fishes are an important part of marine ecosystem. Much like other species, fish contain rich source of antimicrobial peptides which exhibit broad spectrum activity that kills pathogens of fish as well as human s. Teleost fish have received much interest in recent decades owing to the existence of unique bioactive compounds, which exhibit multifunctional properties and act as most promising candidate for pharmaceutical industry with potential application in human health. Antibiotic misuse have accelerated the emergence of drug resistant bacteria, antioxidant stress and chemotherapy related side effects, necessitating the development of new structurally novel drugs to combat them. In this research, based on the in-silico analysis from the freshwater teleost striped murrel Channa striatus (Cs) cDNA library, we identified three different immune genes namely Serine Theronine Protein Kinase (STPK), CxxC Zinc Finger Protein (CxxCZFP), and Histone Acetyl Transferase (HAT) newline