Synthesis, characterization and biological activities of novel hybrid molecules related to substituted hydrazones, sulphonamides and sulphonates of non-steroidal anti inflammatory drugs

Abstract

CHAPTER 1 A Brief Overview of Synthesis and Pharmacological newlineActivities of Substituted Hydrazones, Sulphonates and Sulphonamides This chapter deals with general survey of the literature related to the present topic which describes pharmacological importance, synthesis and the synthetic utility of substituted hydrazones, sulphonates and sulphonamides. N-acyl hydrazones which are pharmacologically important has been combined with Non-steroidal anti-inflammatory drugs such as Naproxen and Ibuprofen drugs used for the treatment of inflammation and also used as an antipyretic agents. There are conditions when an inflammation occurs in response to a microbial infection, and a combination of the anti-inflammatory drug with antimicrobial agent is prescribed in such conditions. These combinations often cause side effects because of high doses of drugs. Searching for new compounds, which would combine two activities seem to be promising way to overcome that problem. Sulfonates and sulfonamides as we know that these are the main drugs which are used as antibacterial agents. In light of theseobservations, we became interested in the synthesis, characterization and biological evaluation of hybrid molecules related to N-acyl hydrazones, sulfonates and sulfonamides. In order to assess more accurately and to provide a background frame work for the work described in this thesis, a survey was undertaken of the relevant literature. The details of synthesis and phamacological activity were presented in this chapter.CHAPTER 2 Synthesis, characterization, cytotoxic and antibacterial study of Naproxen derivatives This chapter deals with a detailed study of synthesis, characterization and cytotoxicity activity propionic acid based hybrid molecules related to Naproxen (1) and N acylhydrazones (Scheme 1). Pharmacological importance of N-acylhydrazones and the gastro intestinal side effects of Naproxen prompted us to plan the synthesis of new derivatives containing both the skeletons.