STUDIES IN FORMULATION DEVELOPMENT OF INSULIN BY ORAL DRUG DELIVERY

Abstract

newlineThe current research work was designed to rise above cited predicament. Microspheres based colon specific drug delivery systems were expected to effectively target bioactive compounds and increase residence time as well. newlineMicrospheres are biologically inert, nonirritating, nonmutagenic, nonallergic, nontoxic polymeric drug delivery systems, which have exposed huge potential in the delivery of drugs at desired site. Microspheres can also be described as porous microspheres, which are fabricated by using cross-linked polymers (mainly substituted acrylates or styrene-divinyl benzene). newlineThis study encompassed training and assessment of Microspheres based colon specific tablet formulations. Initially, Microspheres of Insulin was prepared by quasi-emulsion solvent diffusion method using Eudragit RL 100 and Eudragit L-100. The reason for preparing microsphere due to earlier reports, which suggested that drug carrier, systems less than 200 and#956;m may efficiently be taken up by the macrophages present in colon tissue, thus exhibiting effective localized drug action at the desired site. A subsequent increase of residence time that may be postulated for Microspheres as compared to existing drug delivery systems may allow dose reduction and enhance therapeutic effect. Another reason for preparing Microspheres was their sponge like texture because of which they can easily be compressed to produce mechanically strong tablets.Thus, it can be concluded that CPDRS1 formulation is shows better results and hence, Insulin as anti Diabetis can be successfully delivered as microspheres. newlineEffect of drug-polymer ratio on the size of Microspheres and Effect of amount of emulsifying agent on the production yield and size of Microspheres Optimization of newlineInsulin loaded Eudrajit L microspheres Eudrajit RL and conclude that proper concentration of polymer and emulsification agents give us better formulation and production yield. newline newline newline